Phenergan for Nausea

Page content

Phenergan for nausea is also referred to as promethazine. It is usually used for nausea associated with surgery. It may also be used to sedate and relax patients, and with other medications for anaphylaxis and pain. This medication is classified as a phenothiazines. This medication works through blocking certain natural substances’ reactions within the body.


Administration depends on why this medication is being used. When used in the treatment or prevention of vomiting or nausea, the patient will generally take a dose about every four to six hours. A medical doctor must determine the dose. This medication must absolutely be taken exactly as directed and never more often. Most patients will receive the liquid or tablet form.

Why Does it Help with Nausea?

Phenergen for nausea works by blocking histamine receptors which is likely the cause of many of this drug’s effects. However, this medication also works to block acetylcholine receptors. It is believed that this reaction makes the medication effective in relieving motion sickness and nausea.

Side Effects

Phenergan can cause many side effects. Common side effects include dry mouth, listlessness, nightmares, ringing in ears, loss of coordination, vomiting, restlessness, abnormally happy mood, itching, drowsiness, trouble staying or falling asleep, dizziness, blurred or double vision, nausea, nervousness, hyperactivity and stuffy nose.

Serious side effects include wheezing, stopped breathing for a short time, sweating, decreased alertness, faintness, confusion, seizures, unusual bleeding or bruising, uncontrolled eye movements, abnormal neck position, jaundice, hives, hoarseness, slowed breathing, fever, stiff muscles, irregular or fast heartbeat or pulse, uncontrollable or abnormal movements, hallucinations, unimaginable or overwhelming emotion or fear, uncontrollable shaking, signs of infection, tongue sticking out, inability to respond to people, rash, swelling and difficulty swallowing or breathing.


Certain patients should probably avoid taking Phenergan for nausea. These include those with a promethazine allergy, being unconscious, lung and breathing problems, immune system or blood problems, heart disease, liver disease, seizure, medication-related sun sensitivity, narrow-angle glaucoma, high blood pressure, nervous system issues, bowel or stomach problems, urination problems and pregnancy.

This medication may also have an impact on laboratory testing. These may cause a false positive for blood sugar tests, pregnancy tests, skin tests for allergies, and others.

Drug Interactions

Certain drugs may interact with Phenergan. These include metrizamide, epinephrine for hypotension, sibutramine, anticholinergics, guanethidine, cancer chemotherapy, guanadrel, MAO inhibitors, other antihistamines, anxiety of sleep drugs, narcotics, anti-seizure drugs, muscle relaxers and psychiatric medications.

Other contraindicated drugs include bupropion, phenothiazines, tramadol, isoniazid, theophylline and tricyclic antidepressants. Other drugs may also be affected so all patients must tell their doctor about all current and recent medications taken.


MedlinePlus. (2011). Promethazine. March 14, 2011 from MedlinePlus:

PubMed Health. (2011). Promethazine. Retrieved on March 14, 2011 from PubMed Health: