Intestinal metaphasia is a symptom of Gastritis
Gastritis is the inflammation of the gastric mucosa. It is caused by several factors such as, H pylori infection, NSAIDs, alcohol, stress and autoimmune diseases. Chronic gastritis is associated with atrophy (loss of function of the mucosa) or metaplasia. There are two types of metaplasia commonly found in chronic gastritis:
Mucous gland metaplasia
It is characterized by the replacement of gastric glands with mucous glands. Gastric ulcers tend to be present in this condition. However, it still not fully elucidated whether these ulcers are the cause or consequence of the metaplasia.
Focal intestinal metaplasia
It is typically in response to chronic mucosal injury. The gastric mucosa cells change to resemble those of the intestinal mucosa. Intestinal metaplasia can be classified as either complete, a condition in which all the gastric mucosa have been transformed into small-bowel mucosa, or incomplete, where the epithelium assumes an appearance similar to that of the large intestine.
Intestinal metaplasia is also a common in Barrett esophagus. It this condition it is the esophageal squamous epithelial cells that undergo metaplasia. Approximately, 60% of esophageal cancers diagnosed in the U.S. stem from focal intestinal metaplasia.