In using intravenous conjugated estrogens, one should observe the precautionary measures for this means of administration. To prevent the occurence of flushes, injections should be done in a slow and precise manner.
Premarin intravenous is compatible with some agents such as normal saline, dextrose and invert sugar solutions. It is found incompatible with ascorbic acid, protein hydrolysate, and any solution with an acid pH. The compatibility of solutions must be considered when infusion with other agents has already been started.
Women should discuss with their doctor any medical conditions they have before taking Premarin tablets, or any form of Premarin. Among these health issues are the following:
- Endometrial cancer
- Breast cancer
- Heart disease
- High cholesterol
- Kidney disease
- High blood pressure
- Gall bladder disease
Aside from these conditions, pregnant and breastfeeding women are not advised to take Premarin.
There are medications that should not be taken with Premarin. These drugs can affect how estrogen works, and they can increase the risks of side effects. Among these medications are: barbiturates, rifampin, St. John's wort, meprobamate, phenytoin, protease inhibitors, topiramate, blood pressure lowering agents, antidiabetic agents (insulin, glyburide), corticosteroids and warfarin. The doctor will advise whether taking the medication should be stopped or not.