Common antipsychotic medications for borderline personality disorder include:
1) Haldol (haloperidol)
This medication treats symptoms of dysphoria such as anxiety, rage, depression, and/or despair. It also helps in managing suicidal thoughts, self-destructive impulses and other stress symptoms, which are often present in BPD sufferers.
In terms of effectiveness, haloperidol is more effective in controlling “positive" psychotic symptoms such as delusions and hallucinations than against “negative" symptoms such as social withdrawal.
2) Zyprexa (olanzapine)
It reduces symptoms of “psychoticism" such as depression, interpersonal sensitivity, and anger. It quite effective in decreasing moon swings, anxiety and self-injury in BPD patients. However it is known to cause massive weight gain and patients frequently complain that it causes emotional numbness and mental slowing.
3) Clozaril (clozapine)
It is an atypical antipsychotic drug that has proved to be useful in managing both psychotic symptoms and mood disorders. Clozapine has been found to effectively reduce psychosis; self-injurious behavior (lowers risk of suicide, self-mutilation) decreases aggression and shortens the length of hospital stay for BPD patients.
4) Seroquel (quetiapine)
Research shows this medication to be effective in treating impulsive behavior and other symptoms of borderline personality disorder such as suspiciousness, referential thinking, paranoid ideation, illusions, derealization, depersonalization, or hallucination-like symptoms. Further more it is very effective in the elderly with fewer side effects than Risperdal. Also less likely to cause weight gain.
5) Risperdal (risperidone)
Symptoms of BPD are greatly reduced; some examples are a reduction in aggression, and decrease in depressive symptoms. This medication also effectively increases energy and global functioning in BPD patients.