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Tirofiban Medication Guide

written by: R. Elizabeth C. Kitchen • edited by: Emma Lloyd • updated: 9/10/2010

If you are looking for comprehensive on tirofiban, you are in the right place. Read on to learn about tirofiban warnings and all other important safety information.

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    Tirofiban, the generic version of Aggrastat, is classified as a blood-thinner and platelet aggregation inhibitor. This injectable medication is prescribed to help prevent blood clots that can potentially cause serious blood flow problems or a heart attack. It is administered prior to a variety of medical procedures, such as percutaneous coronary intervention, balloon angioplasty, coronary artery bypass graft, and coronary stent placement. It is also often used in combination with other medications, such as beta-blockers and nitrates, as well as aspirin and heparin. This medication helps to prevent blood clots by preventing blood platelets from sticking to one another.

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    How is this Medication Used?

    This medication is administered intravenously. It can be given over several hours, or other periods of time as prescribed by a doctor. The patient's weight, planned procedure, medical condition, and response to treatment will determine the dose.

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    Side Effects

    As with all medications, this one can cause side effects. Minor irritation or bleeding at the injection site, and dizziness are common following a dose. The most common serious side effect is serious bleeding. The signs of serious bleeding require immediate medical attention and include:

    • Injection site bruising, swelling, bleeding and oozing
    • Fast or irregular heartbeat
    • Pink or red urine
    • Coughing up blood
    • Uncontrolled nosebleed
    • Gray, pale, or bluish skin
    • Stools that are bloody, tarry, or black
    • Coffee ground-looking vomit

    Other serious side effects include (these require immediate medical attention):

    • Chest pain
    • Confusion
    • Weakness
    • Vision problems
    • Slurred speech
    • Decrease in blood platelets
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    Contraindications

    Tirofiban may need to be avoided with the following medical conditions:

    • Current bleeding
    • Bleeding from bladder or gut in prior six weeks
    • Certain heart problems
    • Stroke
    • Serious bleeding in prior 30 days
    • Blood vessel problem in brain
    • Intestinal or stomach problems
    • Bleeding in the eye
    • Liver disease
    • Previously experiencing low platelets with this medication
    • Stroke in previous 30 days
    • Hemorrhagic stroke history
    • Brain tumor
    • Major injury or surgery in prior 30 days
    • Uncontrolled blood pressure that is very high
    • Low blood platelets
    • Kidney disease
    • Recent lumbar puncture, spinal tap, or spinal anesthesia
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    Drug Interactions

    This medication can interact with other medications, both over-the-counter and prescription. Such medications can include:

    • Other blood thinners
    • Anti-platelet drugs
    • Non-steroidal anti-inflammatory drugs
    • Tipranavir
    • Heparin
    • Clopidogrel
    • Warfarin
    • Naproxen
    • Ibuprofen
    • Low-dose aspirin should only be taken when the patient's doctor specifically tells them to take it
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    Warnings and Precautions

    Women who are currently pregnant or want to become pregnant must talk to their doctor before taking this medication. Those who are breastfeeding must also speak to their doctor first. Patients who have had a recent epidural spinal procedure must tell their doctor before taking this medications. It is important that all patients learn about these tirofiban warnings before starting this medication.

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    Resources

    RxList. (2010). Aggrastat. Retrieved on September 7, 2010 from RxList: http://www.rxlist.com/aggrastat-drug.htm

    Drugs.com. (2010). Aggrastat. Retrieved on September 7, 2010 from Drugs.com: http://www.drugs.com/cdi/aggrastat.html